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KMID : 0191120080230040737
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Journal of Korean Medical Science
2008 Volume.23 No. 4 p.737 ~ p.739
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Two Cases of Multidrug-Resistant Human Immunodeficiency Virus Infection Treated with Atazanavir and Lopinavir/Ritonavir Combination Therapy
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Choi Hee-Kyung
Kim Chang-Oh
Choi Jun-Yong
Song Young-Goo
Kim June-Myung
Kim Myung-Soo
Choi Suk-Hoon
Lee Han-Sung
Chin Bum-Sik
Han Sang-Hoon
Chung Soo-Jin
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Abstract
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The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.
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KEYWORD
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Double-Boosted Protease Inhibitor Therapy, Atazanavir, Lopinavir, Salvage Therapy, HIV Infections
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